USP32 grade Vitamin B1 Derivative TPP Thiamine Pyrophosphate
USP32 grade Vitamin B1 Derivative TPP Thiamine Pyrophosphate
Name: Thiamine pyrophosphate
Other Name: Thiamine thiamine pyrophosphate
Product Name: Vitamin B1
CAS Number: 67-03-8
EINECS Number: 200-641-8
Appearance: White to off-white crystalline powder
Specification: PHARM/FOOD/FEED/USP/BP/EP/FCC
Certification: GMP/DMF/HACCP/HALAL/KOSHER
Expiry Time: 3 Years
Packing: 1kg/Tin, 5kg/Tin, 20kg/Drum, 25kg/Drum, 50kg/Drum, 200kg/Drum, 1MT/Drum
Storage: Store in dry places and keep away from strong direct light and heat.
1. Thiamine pyrophosphate is a crystalline, yellow-white, water-soluble compound which is produced by the enzyme thiamine pyrophosphatase.
2. Thiamine pyrophosphate which contains an antithiamine factor (ATF), and chlorinated water tend to destroy B1. Chlorogenic acid, found both in decaffeinated and caffeinated coffee, also destroys B1. • Thiamine is resistant to freezing.
3. The active form, TPP, thiamine pyrophosphate functions as a co-carboxylase. Thiamine HCL is required for the oxidative decarboxylation of pyruvate to form active acetate and acetyl co-enzyme A.
Items | thiamine pyrophosphate Specification | Results |
BP2012 | Appearance | A white or almost white, crystalline powder or small, colorless crystals | White crystalline powder |
Identification | Meet the requirements | Comply |
Appearance of solution | Clear, not more intense than Y7 or GY7 | Comply |
pH | 2.7-3.3 | 3.0 |
Water | ≤ 5.0% | 1.60% |
Sulphated ash | ≤ 0.1% | 0.06% |
Heavy metals | ≤ 20ppm | <10ppm |
Sulphates | ≤ 300ppm | Comply |
Any impurity | ≤0.40 % | 0.13% |
Total impurities | ≤1.0% | 0.41% |
Assay | 98.0%-101.0% | 99.4% |
USP34 | Identification | Meet the requirements | Comply |
pH | 2.7-3.4 | 3.0 |
Water | ≤ 5.0% | 1.60% |
Residue on ignition | ≤ 0.2% | 0.06% |
Absorbance of solution | ≤ 0.025% | Comply |
Limit of nitrate | Meet the requirement | Comply |
Chromatographic purity | Meet the requirement | Comply |
Residual solvent Methanol Ethanol | ≤ 0.3% ≤ 0.5% | Not detected 0.03% |
Assay | 98.0%-102.0% | 99.4% |
Conclusion: All the results conform to the BP2012 and USP34. |