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USP32 grade Vitamin B1 CAS number 67-03-8 Thiamine Hcl
Product name: Thiamine hydrochloride
CAS NO. : 67-03-8
EINECS NO. : 200-641-8
Molecular formula: C12H17ClN4OS · HCl
Molecular weight: 337.27
Melting point : 250 ° C
storage conditions: 2-8 ° C
Thiamine hydrochloride is a form of vitamin B1, USES: nutritional supplements. Vitamin B1 in the middle of the body involved in carbohydrate metabolism.The lack of vitamin B1 in the body and auxiliary carboxylase activity decline, glucose metabolism, thus affecting the whole body metabolic process.The acetone decarboxylation, could not enter the Krebs cycle, do not continue to oxidation, piled up in the organization.At this point, the nervous tissue power is not enough, so can the corresponding neuromuscular symptoms, such as multiple neuritis, muscle atrophy and edema, serious when still can affect the function of myocardial and brain tissue.Vitamin B1 deficiency can also lead to indigestion, loss of appetite and constipation symptoms.
Thiamine hcl vitamin b1 thiamine hydrochloride
Other Name: Thiamine Hydrochloride
Product Name: Vitamin B1 Hydrochloridethiamine thiamine hcl
Other Name: Thiamine Hydrochloride
Molecular Formula: C12H17ClN4OS.HCl
CAS Number: 67-03-8
EINECS Number: 200-641-8
Specification: PHARM/FOOD/FEED/USP/BP/EP/FCC
Certification: GMP/DMF/HACCP/HALAL/KOSHER
Expiry Time: 3 Years
Packing: 1kg/Tin, 5kg/Tin, 20kg/Drum, 25kg/Drum, 50kg/Drum, 200kg/Drum, 1MT/Drum
Storage: Store in dry places and keep away from strong direct light and heat.
Items | Thiamine HCL Specification | Results | |
BP2012 | Appearance | A white or almost white, crystalline powder or small, colorless crystals | White crystalline powder |
Identification | Meet the requirements | Comply | |
Appearance of solution | Clear, not more intense than Y7 or GY7 | Comply | |
pH | 2.7-3.3 | 3.0 | |
Water | ≤ 5.0% | 1.60% | |
Sulphated ash | ≤ 0.1% | 0.06% | |
Heavy metals | ≤ 20ppm | <10ppm | |
Sulphates | ≤ 300ppm | Comply | |
Any impurity | ≤0.40 % | 0.13% | |
Total impurities | ≤1.0% | 0.41% | |
Assay | 98.0%-101.0% | 99.4% | |
USP34 | Identification | Meet the requirements | Comply |
pH | 2.7-3.4 | 3.0 | |
Water | ≤ 5.0% | 1.60% | |
Residue on ignition | ≤ 0.2% | 0.06% | |
Absorbance of solution | ≤ 0.025% | Comply | |
Limit of nitrate | Meet the requirement | Comply | |
Chromatographic purity | Meet the requirement | Comply | |
Residual solvent Methanol Ethanol |
≤ 0.3% ≤ 0.5% |
Not detected 0.03% | |
Assay | 98.0%-102.0% | 99.4% | |
Conclusion: All the results conform to the BP2012 and USP34. | |||
chemistry: • Thiamine HCL is a crystalline, yellow-white, water-soluble compound that is heat and alkali reactive when placed in solution. • In its dry form it is heat and oxygen stable. • Acid tends to make it more stable.
• Black tea, which contains an antithiamine factor (ATF), and chlorinated water tend to destroy B1. Chlorogenic acid, found both in decaffeinated and caffeinated coffee, also destroys B1. • Thiamine is resistant to freezing.
• Rice cooked in chlorinated water had 36% less thiamin than rice cooked in distilled water. Increasing the amount of chlorine decreases the thiamin content even more.
metabolism:
• Thiamine HCL , which is best absorbed in an acid medium, is passively absorbed in the proximal duodenum.
When concentrations are low in the intestine, active transport takes place. • In humans, thiamin can be synthesized in the large intestine as thiamin pyrophosphate (TPP). TPP is too large a molecule to be absorbed across the intestinal mucosa. It requires the use of an enzyme to cleave the smaller thiamin molecule out of the compound. • Allicin, a substance found in onions and garlic, combines with thiamin and renders it more absorbable. • Small amounts of vitamin B1 (30-70 mg) are stored in the body, primarily in muscle tissue.
function: • The active form, TPP, functions as a co-carboxylase. Thiamine HCL is required for the oxidative decarboxylation of pyruvate to form active acetate and acetyl co-enzyme A. It is also required for the oxidative decarboxylation of other alpha-keto acids such as alpha-ketoglutaric acid and the 2 keto-carboxylates derived from the amino acids methionine, threonine, leucine, isoleucine and valine. TPP is also involved as a co-enzyme for the transketolase reaction, which functions for the pentose monophosphate shunt pathway. • TPP has a specific role in neurophysiology separate from its co-enzyme function. It works at the nerve cell membrane to allow displacement so that sodium ions can freely cross the membrane. Thiamine HCL is needed for the metabolism of carbohydrates, fat, and protein. It is especially involved in carbohydrate metabolism in the brain.
dietary sources: Pork, liver, chicken, fish, beef, wheat germ, dried yeast, cereal products, lentils, potatoes, brewer's yeast, rice polishings, most whole grain cereals, especially wheat, oats, and rice, all seeds and nuts, beans, especially soybeans, milk and milk products, vegetables such as beets, green leafy vegetables.
